The thorny path linking cellular senescence to organismal aging
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چکیده
منابع مشابه
The thorny path linking cellular senescence to organismal aging.
Half a century is fast approaching since Hayflick and colleagues formally described the limited ability of normal human cells to proliferate in culture (Hayflick and Moorhead, 1961). This finding – that normal somatic cells, in contrast to cancer cells, cannot divide indefinitely – challenged the prevailing idea that cells from mortal multicellular organisms were intrinsically ‘immortal’ (Carre...
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The aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited proliferative life span, at the end of which they undergo an irreversible cell cycle arrest known as replicative senescence. Whether cellular senescence contributes to organismal aging has been controversial. We investigated telomere dysfunction, a r...
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ژورنال
عنوان ژورنال: Mechanisms of Ageing and Development
سال: 2005
ISSN: 0047-6374
DOI: 10.1016/j.mad.2005.08.001